How does controlled release work

How does this surgery affect how medications work? Is it true that it can limit full absorption of time-release medication? Many medications can be absorbed normally after gastric bypass surgery.

But certain drugs, including some types of time-release medications, require careful monitoring in people who have had gastric bypass. Gastric bypass is a type of bariatric, or "weight-loss" surgery that works by decreasing the amount of food you can eat at one time and by reducing the body's ability to absorb nutrients from food.

In the most common type of gastric bypass, called a Roux-en-Y gastric bypass, the top portion of the stomach is sealed off from the rest of the stomach, creating a pouch about the size of a walnut. The new pouch can hold only about 1 ounce of food, rather than the 3 pints of food the stomach can normally hold. Capsules consist of drugs and additives within a gelatin shell. The shell swells and releases its contents when it becomes wet.

This usually occurs quickly. The size of the drug particles and the properties of the additives affect how quickly the drug dissolves and is absorbed. Drugs tend to be absorbed more quickly from capsules filled with liquid than from those filled with solid particles. If an orally administered drug harms the stomach lining or decomposes in the acidic environment of the stomach, a tablet or capsule of the drug can be coated with a substance intended to prevent it from dissolving until it reaches the small intestine.

These protective coatings are described as enteric coatings. For these coatings to dissolve, they must come in contact with the less acidic environment of the small intestine or with the digestive enzymes there. However, the coatings do not always dissolve as intended.

The tablet or capsule may be passed intact in the feces, especially in older people. Some drug products are specially formulated to release their active ingredients slowly or in repeated small amounts over time—usually for a period of 12 hours or more. This dosage form is called modified-release, controlled-release, sustained-release, or extended-release. A number of other factors may affect the absorption and bioavailability of a drug taken by mouth.

Physiologic characteristics include. Food, other drugs, and digestive disorders can affect drug absorption and bioavailability. This div only appears when the trigger link is hovered over. Otherwise it is hidden from view. Forgot Username? About MyAccess If your institution subscribes to this resource, and you don't have a MyAccess Profile, please contact your library's reference desk for information on how to gain access to this resource from off-campus. Learn More.

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